Molecular Recognition at the Active Site
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Manuel Ellermann; Roland Jakob-Roetne; Christian Lerner; Edilio Borroni; Daniel
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Article
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2009
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John Wiley and Sons
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English
⚖ 562 KB
Biologically active catechols, such as l-DOPA and the neurotransmitter dopamine, are inactivated by methylation. This reaction is catalyzed by the enzyme catechol-O-methyltransferase (COMT) in the presence of S-adenosylmethionine (SAM) and Mg 2+ ions. [1] Small nitrocatechol-based inhibitors of COMT