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Evidence for reduced copying fidelity of DNA polymerases α, δ, and ε from Novikoff hepatoma cells

✍ Scribed by Gabriele Fox; Odilia Popanda; H. W. Thielmann


Book ID
106124663
Publisher
Springer-Verlag
Year
1997
Tongue
English
Weight
344 KB
Volume
123
Category
Article
ISSN
1432-1335

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✍ Odilia Popanda; Claudia Flohr; Jia-Chun Dai; Andreas Hunzicker; Heinz Walter Thi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB

Mutated constituents of the DNA replication complex might contribute to the mutational load of the genome during tumor development by impairing DNA synthesis as well as cell cycle-related control of DNA replication. To prove or disprove this hypothesis, we looked for mutations in the cDNA sequences