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DNA polymerases α, σ and ε of Novikoff hepatoma cells deviate from those of normal rat liver in physico-chemical and catalytic properties

✍ Scribed by O. Popanda; G. Fox; H. W. Thielmann

Book ID
112784573
Publisher
Springer-Verlag
Year
1995
Tongue
English
Weight
163 KB
Volume
121
Category
Article
ISSN
1432-1335

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A mutation in subunit B of the DNA polym
A mutation in subunit B of the DNA polymerase α–primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase α–primase complex
✍ Odilia Popanda; Claudia Flohr; Jia-Chun Dai; Andreas Hunzicker; Heinz Walter Thi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB

Mutated constituents of the DNA replication complex might contribute to the mutational load of the genome during tumor development by impairing DNA synthesis as well as cell cycle-related control of DNA replication. To prove or disprove this hypothesis, we looked for mutations in the cDNA sequences