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Evidence for oxidative metabolism in the genotoxicity of the atmospheric reaction product 2-nitronaphthalene in human lymphoblastoid cell lines

✍ Scribed by Jennifer C Sasaki; Janet Arey; David A Eastmond; Karyn K Parks; Patricia T Phousongphouang; Andrew J Grosovsky

Book ID
117767867
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
244 KB
Volume
445
Category
Article
ISSN
1383-5718

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## Abstract A human lymphoblastoid cell line stably expressing a human cytochrome P4501A2 cDNA was developed. This recombinant cell line displayed P4501A2 protein and estradiol2‐hydroxylase activity, neither of which was detected in the parental cell line. The recombinant cell line was also approxi