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Evidence for gene conversion in the generation of extensive polymorphism in the promoter of the growth hormone gene

✍ Scribed by Mara Giordano; Cristina Marchetti; Elena Chiorboli; Gianni Bona; P. Momigliano Richiardi


Publisher
Springer
Year
1997
Tongue
English
Weight
65 KB
Volume
100
Category
Article
ISSN
0340-6717

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To assess the evolutionary importance of nonallelic (or interlocus) gene conversion for the highly polymorphic human growth hormone (GH1) gene promoter, sequence variation in this region was studied in four different ethnic groups. For 14 SNPs in the proximal GH1 promoter (535 bp), 60 different hapl

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Growth hormone receptor (GHR) has a major role in the regulation of growth hormone action, and thus, is an obvious candidate gene associated with milk production traits in mammals. The present authors have sequenced 273 bp of the 3β€² flanking region of the bovine __GHR__, and found three length varia