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Evidence for essential thiol groups and disulfide bonds in agonist and antagonist binding to the dopamine receptor

✍ Scribed by Erick T. Suen; Ennio Stefanini; Yvonne C. Clement-Cormier


Book ID
118315087
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
433 KB
Volume
96
Category
Article
ISSN
0006-291X

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The mobility of purified p opioid binding protein in SDS-polyacrylamide gek electrophoresis is sensitive to the presence of reducing agents. In the presence of increasing concentrations of DTT the apparent molecular weight increases in a stepwise fashion from 53 kDa to 65 kDa. This reduction in mobi