Evidence for defective Rab GTPase-dependent cargo traffic in immune disorders

Spontaneous diabetes in BB rats: Evidenc

Spontaneous diabetes in BB rats: Evidence for a T cell dependent immune response defect

✍ D. Bellgrau; A. Naji; W. K. Silvers; J. F. Markmann; C. F. Barker 📂 Article 📅 1982 🏛 Springer 🌐 English ⚖ 616 KB

Approximately 50% of BB rats develop insulinopenic hyperglycaemia and ketosis spontaneously in association with insulitis. Amelioration of the syndrome by immunosuppression suggests a cell mediated immune pathogenesis. Analysis of the cell-mediated immune profile of overtly diabetic and normoglycaem