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Evidence for defective incorporation of proteins in myelin of the quaking mutant mouse

✍ Scribed by Seymour Greenfield; Steven Brostoff; Edward Hogan

Book ID
118863546
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
515 KB
Volume
120
Category
Article
ISSN
0006-8993

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The expression of myelin proteins in actively myelinating quaking and control brains was studied. RNA was extracted from the brains of 18- and 27-day-old mice and analyzed by northern blot using cDNA probes for proteolipid protein (PLP), basic protein (BP), and myelin-associated glycoprotein (MAG).