Increased turnover of myelin proteolipid protein in quaking mouse brain
โ Scribed by G. Konat; G. Gantt; E. L. Hogan
- Book ID
- 112457505
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 232 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0885-7490
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๐ SIMILAR VOLUMES
The expression of myelin proteins in actively myelinating quaking and control brains was studied. RNA was extracted from the brains of 18- and 27-day-old mice and analyzed by northern blot using cDNA probes for proteolipid protein (PLP), basic protein (BP), and myelin-associated glycoprotein (MAG).
A point mutation in the gene for proteolipid protein (PLP) has been suggested to account for the dysmyelination seen in the jimpy mouse mutant, Despite the absence of PLP, the major integral membrane protein of central nervous system (CNS) myelin, this study shows that there are many scattered myeli