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Evidence for an ancestral alphoid domain on the long arm of human chromosome 2

✍ Scribed by Rosamaria Avarello; Antonio Pedicini; Angela Caiulo; Orsetta Zuffardi; Marco Fraccaro

Publisher: Springer
Year: 1992
Tongue: English
Weight: 465 KB
Volume: 89
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00217134

No coin nor oath required. For personal study only.

✦ Synopsis

In situ hybridization, under low stringency conditions with two alphoid DNA probes (pY alpha 1 and p82H) labeled with digoxigenin-dUTP, decorated all the centromeres of the human karyotype. However, signals were also detected on the long arm of chromosome 2 at approximately q21.3-q22.1. Since it is supposed that human chromosome 2 originated by the telomeric fusion of two ancestral primate chromosomes, these findings indicate that not only the telomeric sequences, but also the ancestral centromere (or at least its alphoid sequences), have been conserved.

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