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Evidence for an acetoxyarylamine as the ultimate mutagenic reactive intermediate of the carcinogenic aromatic amine 2,4-diaminotoluene

✍ Scribed by Michael L. Cunningham; H.B. Matthews


Book ID
119093415
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
753 KB
Volume
242
Category
Article
ISSN
0165-1218

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Tbe model reaction of 5 with 6 to give 7 and 8 (>90%) follows the SN~ mechankm. From this result and from product studies it is concluded that the reactions of the ultimate carcinogen 1 with 6 and deoxy8uanosine (dG) (and hence of other ultimate carcino8ens of aromatic amines with biot.mckophiles) f