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Evidence for a ‘silent allele’GLO0at the glyoxalase I locus

✍ Scribed by Ch. Rittner; W. Weber

Publisher
Springer
Year
1978
Tongue
English
Weight
181 KB
Volume
42
Category
Article
ISSN
0340-6717

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✦ Synopsis

In a three-generation family, the segregation of an apparent silent allele at the GLO I locus in association with the rare HLA haplotype 'AW30-CW4-BW35' was observed in four members. In two cases the assumption of homozygosity at the GLO locus would lead to mother-child exclusions. Phenotypically, the GLO activity in the GLO0 carriers is clearly diminished.

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