Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer
โ Scribed by Bao-Li Chang; Elizabeth M. Gillanders; Sarah D. Isaacs; Kathy E. Wiley; Tamara Adams; Aubrey R. Turner; S. Lilly Zheng; Deborah A. Meyers; John D. Carpten; Patrick C. Walsh; Jeffrey M. Trent; Jianfeng Xu; William B. Isaacs
- Book ID
- 116333403
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 190 KB
- Volume
- 219
- Category
- Article
- ISSN
- 0304-3835
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## BACKGROUND. Two genes responsible for hereditary breast cancer (BRCA1 and BRCA2) have been identified, and predisposing mutations identified. Several studies have provided evidence that germline mutations in BRCA1 and BRCA2 confer an increased risk of prostate cancer. Based on these findings, o
To date, 2 major breast cancer and/or ovarian cancer predisposition genes have been identified. However, a significant proportion of families with multiple cases of breast cancer cannot be explained by mutations in the BRCA1 and BRCA2 genes, 1 especially in the Nordic populations. [2][3][4] In addit