Evidence for a BRCA1 Founder Mutation in Families of West African Ancestry
β Scribed by Heather C. Mefford; Lisa Baumbach; Ramesh C.K. Panguluri; Carolyn Whitfield-Broome; Csilla Szabo; Selena Smith; Mary-Claire King; Georgia Dunston; Dominique Stoppa-Lyonnet; Fernando Arena
- Book ID
- 117852939
- Publisher
- American Society of Human Genetics
- Year
- 1999
- Tongue
- English
- Weight
- 593 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/302511
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## Abstract Germβline mutations within __BRCA1__ are responsible for different proportions of inherited susceptibility to breast/ovarian cancer, and the spectrum of mutations within this gene is often unique to certain populations. At this time, there have been no reports regarding the role of __BR
## Abstract Three mutations in __BRCA1__ (5382insC, C61G and 4153delA) are common in Poland and account for the majority of mutations identified to date in Polish breast and breastβovarian cancer families. It is not known, however, to what extent these 3 founder mutations account for all of the BRC