Evaluation of99mTc-labeled antibiotics for infection detection
โ Scribed by Fatma Yurt Lambrecht
- Book ID
- 107615368
- Publisher
- Springer Japan
- Year
- 2010
- Tongue
- English
- Weight
- 519 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0914-7187
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## Abstract The optimization of the radiolabeling yield of ciprofloxacin analogous, difloxacin and pefloxacin, with ^99m^Tc was described. At pH 4, difloxacin was labeled with ^99m^Tc with a labeling yield of 95.6% by adding ^99m^Tc to 5โmg difloxacin in the presence of 100โยตg SnCl~2~ยท2H~2~O wherea
Three immunoglobulin molecules were evaluated as infection imaging agents in a rat model of S. aureas infection: 99m Tc-infliximab, 99m Tc-human immunoglobulin (HIG) and 99m Tc-rat immunoglobulin (RIG). Infliximab is a chimeric monoclonal antibody specific for human tumour necrosis factor alpha (TNF