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Evaluation of triple quantum-filtered 23Na NMR spectroscopy in the in situ rat liver

✍ Scribed by Viswanathan Seshan; A. Dean Sherry; Navin Bansal

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 746 KB
Volume: 38
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910380519

No coin nor oath required. For personal study only.

✦ Synopsis

Triple quantum (TQ)-filtered 23Na NMR spectroscopy and the shift reagent, TmDOTP5-, have been used to evaluate the contributions of intra- (Na+i) and extracellular (Na+e) sodium to the TQ-filtered signal in the rat liver, in situ. Na+e contributed significantly to the total TQ-filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ-filtered Na+i signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Na+i increased by 90%. The constancy of the TQ-filtered Na+i signal indicates that changes in total TQ-filtered 23Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ-filtered Na+i signal intensity. The large percent increase in the TQ-filtered Na+i signal as compared to the SQ signal suggests that the fraction of Na+i interacting with macromolecules increases after death.

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