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Complete elimination of the extracellular 23Na NMR signal in triple quantum filtered spectra of rat hearts in the presence of shift reagents

✍ Scribed by Gil Navon

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 326 KB
Volume: 30
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910300415

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✦ Synopsis

Abstract

A method is suggested whereby the shifted extracellular triple quantum filtered ^23^Na signal of an isolated organ is completely eliminated. The method is based on the long relaxation time of the triple quantum coherence and on its fast evolution rate. When the carrier frequency is set on top of the intracellular sodium signal and the time interval between the last two pullses to (12 Δ__v__)‐l (Δ__v__ is the frequency difference between the intiracellular and the extracellular signals), a complete elimination of the extracellular ^23^Na signal is achieved. The method is demonstrated for isolated rat hearts and the quantification of intracellular sodium using triple quantum filtered spectroscopy is discussed.

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