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Evaluation of three assays for the determination of serum total sialic acid

✍ Scribed by M. Crook; M. Haq; P. Tutt

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 371 KB
Volume: 26
Category: Article
ISSN: 0009-9120
DOI: 10.1016/0009-9120(93)80008-i

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✦ Synopsis

There is increasing clinical interest in the measurement of serum total sialic acid (TSA). There are a number of methods available but with little data suggesting the preferred technique. We evaluated three serum sialic acid assays: the Warren assay, the Svennerholm assay, and a commercially available enzymatic method. The analytical performances of the three assays were similar, except that the enzymatic assay had a greater analytical range than the other assays and better precision at low and high serum sialic acid concentrations. The enzymatic assay was readily automated for use on a Cobas Bio analyser but was substantially more expensive than the other two methods.

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