Evaluation of serum sialic acid and carcinoembryonic antigen for the detection of early-stage colorectal cancer

✍ Scribed by Carmen Tautu; Jack A. Alhadeff; David Pee; Marlene Dunsmore; Joseph J. Prorok

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 651 KB
• Volume: 5
• Category: Article
• ISSN: 0887-8013
• DOI: 10.1002/jcla.1860050405

✦ Synopsis

Various expressions of elevated serum sialic acid (total sialic acid, TSA: lipid-associated B) colorectal cancer. However, TSA and TSAlTP values were siclnificantlv elevated in sialic acid, LASA; LASAlTSA; TSA normalized to total protein, TSMP) have been evaluated and compared with increased serum carcinoembryonic antigen (CEA) levels for the detection of early-stage coloredal cancer. This evaluation was done blindly on a coded panel of 320 sera from staged colorectal cancer patients and controls provided by the Mayo Clinic-National Cancer Institute Diagnostic Bank. Unlike the findings of a previous preliminary study (Tautu et al., JNCl 80:1333-1337, 1988), the ratio of LASmSA was not useful for detecting early-stage (Dukes A and each colorectal cance;subgroup compared with normal controls. TSA and TSAlTP values displayed a marginally better discriminatory power than CEA values in the case of Dukes A subgroup with respect to normal controls. CEA still appears to be the best single overall marker for discriminating between colorectal cancers and controls. However, multiple marker analysis using CEA and TSA (and related markers) appears to be more sensitive than CEA alone for detecting colorectal cancer.