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Evaluation and limitations of the lipid-associated sialic acid test for the detection of human cancer

โœ Scribed by Rudolf Voigtmann; Juergen Pokorny; Arne Meinshausen

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
470 KB
Volume
64
Category
Article
ISSN
0008-543X

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โœฆ Synopsis

Previous studies and those of the authors have reported about raised levels of lipid-bound sialic acid (LSA) in sera of patients with various neoplasms. Most authors have used the method of Katopodis and Stock for isolating serum LSA. Because of the discrepancy of the amount of extracted LSA with the content of pure gangliosides in sera reported by other groups the authors analyzed the composition of the extracted LSA by immunochemical approaches. They were able to isolate considerable amounts of glycoproteins containing sialic acid as acid a-l-glycoprotein, antitrypsin, haptoglobin, antichymotrypsin, and immunoglobulins from the so-called "LSA" fraction. There is a very strong correlation between the raised LSA levels and the content of acid-a-l-glycoprotein in the sera of patients with malignancy. Therefore the term lipid-bound sialic acid applied to this test is misleading, since glycoproteins containing sialic acid are mostly responsible for the high "LSA" levels.

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