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Evaluation of theRHINOgene for breast cancer predisposition in Finnish breast cancer families

✍ Scribed by Heikkinen, Tuomas; Khan, Sofia; Huovari, Elina; Vilske, Sara; Schleutker, Johanna; Kallioniemi, Anne; Blomqvist, Carl; Aittomäki, Kristiina; Nevanlinna, Heli

Book ID
121533453
Publisher
Springer US
Year
2014
Tongue
English
Weight
176 KB
Volume
144
Category
Article
ISSN
0167-6806

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## Abstract The genes predisposing to familial breast cancer are largely unknown, but 5 of the 6 known genes are involved in DNA damage repair. RAD50 is part of a highly conserved complex important in recognising, signalling and repairing DNA double‐strand breaks. Recently, a truncating mutation in