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Can Unknown Predisposition in Familial Breast Cancer be Family-Specific?

✍ Scribed by Lynch, Henry; Wen, Hongxiu; Kim, Yeong C.; Snyder, Carrie; Kinarsky, Yulia; Chen, Pei Xian; Xiao, Fengxia; Goldgar, David; Cowan, Kenneth H.; Wang, San Ming

Book ID
121678958
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
229 KB
Category
Article
ISSN
1075-122X

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## Abstract The genes predisposing to familial breast cancer are largely unknown, but 5 of the 6 known genes are involved in DNA damage repair. RAD50 is part of a highly conserved complex important in recognising, signalling and repairing DNA double‐strand breaks. Recently, a truncating mutation in