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Evaluation of theBRCA1interacting genesRAP80andCCDC98in familial breast cancer susceptibility

✍ Scribed by Ana Osorio; Alicia Barroso; Maria J. García; Beatriz Martínez-Delgado; Miguel Urioste; Javier Benítez


Book ID
106378110
Publisher
Springer US
Year
2008
Tongue
English
Weight
216 KB
Volume
113
Category
Article
ISSN
0167-6806

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## Abstract The genes predisposing to familial breast cancer are largely unknown, but 5 of the 6 known genes are involved in DNA damage repair. RAD50 is part of a highly conserved complex important in recognising, signalling and repairing DNA double‐strand breaks. Recently, a truncating mutation in