Evaluation of the Human Melanoma Targeting Properties of Radiolabeled α-Melanocyte Stimulating Hormone Peptide Analogues
✍ Scribed by Miao, Yubin; Whitener, Donna; Feng, Weiwei; Owen, Nellie K.; Chen, Jianqing; Quinn, Thomas P.
- Book ID
- 126883074
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 94 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1043-1802
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## Abstract Following the first synthesis of tritiated α‐melanocyte‐stimulating hormone (α‐MSH, α‐melanotropin) in 1974 by Medzihradszky __et al.__, several α‐MSH analogs were designed containing between 2 and 12 tritium atoms, the latter of which displayed a specific radioactivity of 12.21 GBq/μmo
Six alpha-MSH(4-10) [Nle-Asp-His-D-Phe-Arg-Trp-Lys-amide] derivatives carrying 2 or 1 or no 2,3-dihydroxy-(2S)-propyl (DHP) groups on the Lys10 amino side chain were coupled to diethylene-triaminopentaacetic acid (DTPA, a chelator for 111In) in monomeric and dimeric forms and tested for their bindin