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Evaluation of the effects of intravascular MR contrast media (gadolinium dendrimer) on 3D time of flight magnetic resonance angiography of the body

✍ Scribed by Michael W. Bourne; Larry Margerun; Nola Hylton; Brian Campion; Jan-Ji Lai; Nikita Derugin; Charles B. Higgins

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
785 KB
Volume
6
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

The aims of this preliminary study were to establish the efficacy and minimum effective dose of TG~5~(FdDO3A)~52~ gadolinium dendrimer for contrast‐enhanced, three‐dimensional (3D) time of flight (TOF) magnetic resonance angiography (MRA) of the body. In a dose ranging study in eight rabbits (Group A), each of two animals received 0.03; 0.02; 0.01; or 0.005 mmol/kg of the agent for 3D‐TOF MRA of the pelvic circulation in the axial and coronal planes. An additional nine animals (Group B) received a dose of 0.02 mmol/kg for 3D‐TOF MRA of the mediastinum, abdomen or of the lower limbs. Quantitative and qualitative analyses of the images from Group A demonstrated a dose‐related reduction in saturation effects and improved visualization of vascular structures, with maximal augmentation of the contrast‐to‐noise ratio (CNR) at 0.03 mmol/kg. The dose of 0.02 mmol/kg was found to be the minimal effective dose at the three vascular regions.

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