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Evaluation of the effects of alcohol, a high-fat breakfast, and a moderate-fat evening meal on the pharmacokinetics of the PDE5 inhibitor vardenafil

✍ Scribed by R.J. Bauer; G. Rohde; P. Rajagopalan

Book ID
118644849
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
218 KB
Volume
2
Category
Article
ISSN
1569-9056

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## Abstract The effect of obesity induced by a high‐fat diet on the pharmacokinetics (PK) of nelfinavir (NFV) was investigated, focusing on the change of distribution and elimination caused by dyslipidemia and hepatic steatosis. The plasma unbound fraction (__f__~u~) of NFV in obese rats (0.61Β±0.0