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Evaluation of the activity of HIV-1 integrase over-expressed in eukaryotic cells

✍ Scribed by Bénédicte Van Maele; Leen Van Eylen; Wim Pluymers; Zeger Debyser

Book ID
116289682
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
501 KB
Volume
327
Category
Article
ISSN
0006-291X

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✍ Johan van Griensven; Xiaojing Zhan; Bénédicte Van Maele; Wim Pluymers; Martine M 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 247 KB

## Abstract ## Background HIV‐1 integrase (IN) is an interesting target for the gene therapy of AIDS. Although the __in vivo__ functions are not well characterized, it is thought that IN has pleiotropic effects and plays a central role in the interplay between the virus and the host cell. Expressi