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Active site binding modes of curcumin in HIV-1 protease and integrase

✍ Scribed by Opa Vajragupta; Preecha Boonchoong; Garrett M. Morris; Arthur J. Olson


Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
645 KB
Volume
15
Category
Article
ISSN
0960-894X

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The HIV-1 integrase, which is essential for viral replication, catalyzes the insertion of viral DNA into the host chromosome thereby recruiting host cell machinery into making viral proteins. It represents the third main HIV enzyme target for inhibitor design, the first two being the reverse transcr