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Evaluation of skin sensitization potential of melatonin and nimesulide by murine local lymph node assay

โœ Scribed by Narayanasamy Kanikkannan; Tanise Jackson; Madhu Sudan Shaik; Mandip Singh


Book ID
114301926
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
56 KB
Volume
14
Category
Article
ISSN
0928-0987

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The local lymph node assay (LLNA) is used to assess the skin sensitization potential of chemicals. In the standard assay, mice are treated topically on the dorsum of both ears with test substance for 3 days. Following 2 days of rest, the initiation of the hypersensitivity response is evaluated by in