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Evaluation of radiolabeled bombesin analogs in animals

โœ Scribed by Subhani M. Okarvi

Publisher
Springer US
Year
2007
Tongue
English
Weight
62 KB
Volume
108
Category
Article
ISSN
0167-6806

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The 14-aminoacid peptide bombesin (BN) has a high affinity for the gastrin-releasing peptide receptor which is expressed by a variety of tumours. Thus, radiometal-labelled DTPA-BN derivatives are potentially useful radioligands for receptor-targeted scintigraphy and radiotherapy of BN receptor-expre

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Preclinical evaluation of therapeutic effects of targeted cytotoxic analogs of somatostatin and bombesin on human gastric carcinomas
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## Abstract ## BACKGROUND New modalities are necessary for the treatment of patients with unresectable gastric carcinoma. The authors investigated whether receptors for somatostatin and bombesin were present in human gastric carcinoma lines and tested the antitumor effects of cytotoxic somatostati