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18F-radiolabeled analogs of exendin-4 for PET imaging of GLP-1 in insulinoma

✍ Scribed by Dale O. Kiesewetter; Haokao Gao; Ying Ma; Gang Niu; Qimeng Quan; Ning Guo; Xiaoyuan Chen

Book ID
105964581
Publisher
Springer
Year
2011
Tongue
English
Weight
576 KB
Volume
39
Category
Article
ISSN
0340-6997

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## Abstract 4‐Fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)piperazin‐1‐yl]ethyl}benzamide is a full 5‐HT~1A~ agonist with high affinity (__pK__~__i__~=9.3), selectivity and a __c__ log __P__ of 3.045. The corresponding PET radioligand 4‐[^18^F]fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)