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Evaluation of pharmacokinetic differences of acetaminophen in pseudo germ-free rats

✍ Scribed by Soo Hyun Lee; Ji Hye An; Hwa Jeong Lee; Byung Hwa Jung

Book ID
115550721
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
479 KB
Volume
33
Category
Article
ISSN
0142-2782

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## Abstract The pharmacokinetics of noreximide in the rat after i.v., p.o., and i.p. administration was studied. The biologic half‐life of approximately 8 h was found almost the same for all three routes. Upon p.o. administration the fraction of drug absorbed is 85 per cent, and the peak concentrat