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Evaluation of Loxoprofen and Its Alcohol Metabolites for Potency and Selectivity of Inhibition of Cyclooxygenase-2.

✍ Scribed by Denis Riendeau; Myriam Salem; Angela Styhler; Marc Ouellet; Joseph A. Mancini; Chun Sing Li

Book ID
101956847
Publisher
John Wiley and Sons
Year
2004
Weight
72 KB
Volume
35
Category
Article
ISSN
0931-7597

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✍ Tae-Sung Koo; Dae-Hyun Kim; Sung-Hoon Ahn; Kang-Pil Kim; In-Wha Kim; Seung-Yong πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 146 KB

The objective of this study was to characterize the extent of the formation of the active (trans-alcohol form) and inactive (cis-alcohol) metabolites of loxoprofen and to compare the kinetics after its intragastric, intravenous, and intramuscular administrations in rats. After intravenous administra