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Evaluation of epstein-barr virus antibody patterns and detection of viral markers in the biopsies of patients with Hodgkin's disease

✍ Scribed by Paul H. Levine; Gorm Pallesen; Peter Ebbesen; Nancy Harris; Alfred S. Evans; Nancy Müeller

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
340 KB
Volume
59
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

We assessed the relationship of Epstein‐Barr virus (EBV) serology to the presence or absence of EBV genome in 39 cases of Hodgkin's disease (HD). Biopsies from patients included in 2 previous published studies, I involving patients from the United States (eastern Massachusetts) and I from Denmark, were evaluated for EBV RNA (EBER‐1) and latent membrane protein (LMP‐I). The presence of EBV in Reed‐Sternberg cells in the biopsies correlated with the histologic subtype of HD (mixed cellularity and lymphocyte depletion) but not with IgG antibody titers against the viral capsid antigen (VCA). These data suggest that, unlike Burkitt's lymphoma, the IgG antibody against VCA is not predictive of the presence or absence of EBV in Reed‐Sternberg cells in HD. The predictive value of other antibodies should be evaluated.

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