Evaluation of enantioselective binding of basic drugs to plasma by ACE
✍ Scribed by María Amparo Martínez-Gómez; Rosa María Villanueva-Camañas; Salvador Sagrado; Maria José Medina-Hernández
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 275 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0173-0835
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📜 SIMILAR VOLUMES
The enantioselective protein binding of mephobarbital (MPB) was investigated in human plasma and human serum albumin solutions by equilibrium dialysis. A small but statistically significant difference was observed in the in vitro plasma protein binding of the enantiomers; (S)-MPB was -59% bound and
The plasma protein binding of drugs has been shown to have significant effects on the quantitative relationship between clinical pharmacokinetics and pharmacodynamics. In many clinical situations, measurement of the total drug concentration does not provide the needed information concerning the unbo