𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology

✍ Scribed by N. C. Henney

Book ID
111792124
Publisher
Springer
Year
2010
Tongue
English
Weight
141 KB
Volume
72
Category
Article
ISSN
0009-5893

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Comparative preclinical drug metabolism
Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials
✍ Charles B. Davis; Ramesh Bambal; Ganesh S. Moorthy; Erin Hugger; Hong Xiang; Bri πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 202 KB

The disposition of three 4-aminoquinoline leads, namely isoquine (ISO), des-ethyl isoquine (DEI) and N-tert-butyl isoquine (NTBI), were studied in a range of in vivo and in vitro assays to assist in selecting an appropriate candidate for further development. Analogous to amodiaquine (ADQ), ISO under

Preclinical drug metabolism and pharmaco
Preclinical drug metabolism and pharmacokinetic evaluation of GW844520, a novel anti-malarial mitochondrial electron transport inhibitor
✍ Hong Xiang; Jeanelle McSurdy-Freed; Ganesh S. Moorthy; Erin Hugger; Ramesh Bamba πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 192 KB

GW844520 is a potent and selective inhibitor of the cytochrome bc1 complex of mitochondrial electron transport in P. falciparum, the parasite primarily responsible for the mortality associated with malaria worldwide. GW844520 is fully active against the parasite including resistance isolates, showin