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Evaluation of copper chelation agents as anti-angiogenic therapy

✍ Scribed by Kevin Camphausen; Mary Sproull; Steve Tantama; Sandeep Sankineni; Tamalee Scott; Cynthia Ménard; C.Norman Coleman; Martin W Brechbiel

Book ID
108479378
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
200 KB
Volume
11
Category
Article
ISSN
0968-0896

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Thirty-eight tea polyphenols were evaluated for their inhibitory effect against HIV replication in H9 lymphocyte cells. 8-C-Ascorbyl (-)-epigallocatechin (13) and theasinensin-D (32) demonstrated relatively potent anti-HIV activity with EC50 values of 4 and 8 tlg/mL and therapeutic indexes of 9.5 an