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Evaluation of cell-mediated reactivity and serum blocking factors in melanoma patients on chemotherapy

✍ Scribed by Cummings, F. J. ;Heppner, Gloria H. ;Calabresi, Paul ;Byrne, Michael ;Stolbach, Leo

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
553 KB
Volume
1
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

Sequential assays for cell‐mediated reactivity (CMR) and serum blocking factor (SBF) were performed in a group of 12 melanoma patients who were treated with one or both of the clinically available imidazole carboxamide derivatives, DTIC* and TIC† Mustard, in order to consider the effects of treatment and changing patterns of disease on the results of in vitro tests in individual patients. Microcytotoxicity assays and the dilute agar colony inhibition test were employed. Of the 12 patients, 8 had no change in CMR and 5 had no change in SBF. Three patients demonstrated a fall in both CMR and SBF to nondetectable levels, and 3 additional patients showed a fall in SBF only. From these results, we conclude that there is no significant.

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