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Serum factors in tumor-free patients cancelling the blocking of cell-mediated tumor immunity

✍ Scribed by Ingegerd Hellström; Karl Erik Hellström; Hans Olov Sjögren; Glenn A. Warner

Publisher
John Wiley and Sons
Year
1971
Tongue
French
Weight
486 KB
Volume
8
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

It has been previously shown that lymphocytes from cancer patients can kill cultivated neoplastic cells of the type carried by the lymphocyte donors and that sera from patients with growing tumors of the respective types can specifically block the tumor‐cell destruction. The present study demonstrates that sera from all of seven tumor patients tested (one with melanoma, one with colonic carcinoma and four with breast carcinoma), who had become clinically tumor‐free, could “unblock” ( = abrogate) the blocking effect of sera from patients bearing tumors of the respective types, thus making it possible for immune lymphocytes to kill cultivated neoplastic cells in the combined presence of the “unblocking” and blocking sera.

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