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Evaluation of cardiotoxicity of a new anthracycline derivative: 4′ -deoxy-4′ -iodo-doxorubicin

✍ Scribed by Fabrizio Villani; Milena Galimberti; Enrica Lanza; Annalinda Rozza; Luigia Favalli; Paola Poggi

Book ID
104652254
Publisher
Springer US
Year
1988
Tongue
English
Weight
395 KB
Volume
6
Category
Article
ISSN
0167-6997

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✍ Rosanna Supino; Mariangela Mariani; Ennio Prosperi; Giorgio Parmiani 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 433 KB

A B16 melanoma cell line in which resistance to doxorubicin (Dx) had been induced by in vitro exposure to the drug, was found not to be cross-resistant with 4'-deoxy-4'-iodo-doxorubicin (4'-I-Dx), a new Dx derivative. Dx was 200 times less active in resistant than in sensitive cells, whereas the iod