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Cardiotoxicity and cytotoxicity of the anthracycline analog 4′-deoxy-4′-iodo-doxorubicin

✍ Scribed by Romano Danesi; Nunzia Bernardini; Cristiana Agen; Mario Costa; Paolo Macchiarini; Paola Della Torre; Mario Del Tacca


Book ID
107937754
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
586 KB
Volume
70
Category
Article
ISSN
0300-483X

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Comparativein vitroactivity of 4′-deoxy-
✍ Jonathan E. Schwartz; Sydney E. Salmon 📂 Article 📅 1987 🏛 Springer US 🌐 English ⚖ 266 KB

A new halogenated anthracycline analog 4'-deoxy-4'-iododoxorubicin (IODO) was compared with doxorubicin (DOX) and deoxydoxorubicin (DEOX) in the human tumor clonogenic assay (HTCA) using human tumor cell lines. For all cell lines tested, IODO had lower ID50 value and thus greater in vitro potency an