๐”– Bobbio Scriptorium
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Evaluation of Carbodiimides Using a Competition Method

โœ Scribed by Jan Izdebski; Danuta Kunce

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
44 KB
Volume
3
Category
Article
ISSN
1075-2617

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โœฆ Synopsis

A competitive reaction of activated Boc-Ala-OH and Boc-Phe-OH with H-Leu-resin has been developed for assessing the relative efficiencies of different carbodiimides. This allowed a comparison of the efficiency of the carbodiimides N,N 0 -dicyclohexylcarbodiimide,N,N 0 -diisopropylcarbodiimide, N-tert-butyl-N 0 - methylcarbodiimide and N-tert-butyl-N 0 -ethylcarbodiimide. Comparable results were obtained when these reagents were used for the preformation of symmetrical anhydrides or of 1-hydroxybenzotriazole esters in situ. Differential incorporation was observed when asymmetrical carbodiimides were used for peptide bond formation by the direct carbodiimide procedure.

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