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Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin

โœ Scribed by Jennifer Venhorst; Rob C.A Onderwater; John H.N Meerman; Nico P.E Vermeulen; Jan N.M Commandeur


Book ID
114301785
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
134 KB
Volume
12
Category
Article
ISSN
0928-0987

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Validation of higher-throughput high-per
โœ Inhou Chu; Leonard Favreau; Tony Soares; Chin-chung Lin; Amin A. Nomeir ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 166 KB ๐Ÿ‘ 2 views

In the early stage of drug discovery, thousands of new chemical entities (NCEs) may be screened before a single drug candidate can be identified for development. In order to accelerate the drug discovery process, we have developed higher-throughput enzyme assays to evaluate the inhibition of cytochr