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Evaluation of a new automated third-generation anti-HCV enzyme immunoassay

✍ Scribed by D. Lavanchy; J. Steinmann; A. Möritz; P. C. Frei

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 506 KB
Volume: 10
Category: Article
ISSN: 0887-8013
DOI: 10.1002/(sici)1098-2825(1996)10:5<269::aid-jcla7>3.0.co;2-3

No coin nor oath required. For personal study only.

✦ Synopsis

The new Cobas Core Anti-HCV EIA was evaluated in two centers for its ability to detect antibodies directed to hepatitis C virus in human serum. This assay, which can be run fully automated on a random access analyzer, was compared with three other commercially available screening tests: the Ortho HCV 3.0 ELISA, the Murex anti-HCV, and theAbbotl HCV EIAsecond generation. Posi- tive or discrepant results were further investigated using the Wellcozyme HCV Western Blot or the Abbott Matrix HCV assays.

The results obtained from analyzing 5045 serum samples showed a high correlation between the Cobas CoreAnti-HCV ElAand the other screening assays, ranging from 98.9% to 99.9%. Diagnostic specificities and sensitivities ranged from 99.7% to 100% and from 98.8% to loo%, respectively. In this study, the Cobas Core Anti-HCV EIA proved to be a very convenient test, able to perform at the highest levels of sensitivity and specificity. o 1996 Wiley-Liss, Inc.

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