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Evaluation of a method for simultaneous quantification of codeine, ethylmorphine and morphine in blood

✍ Scribed by Hallvard Gjerde; Unni Fongen; Hans Gundersen; Asbjørg S. Christophersen

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
404 KB
Volume
51
Category
Article
ISSN
0379-0738

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✦ Synopsis

Codeine, ethylmorphine and morphine are the most commonly detected opiates in forensic blood samples in Norway. A method for the simultaneous quantification of these opiates utilizing solid phase extraction and gas chromatography-mass spectrometry has been evaluated. The detection limits were 0.026 mumol/l for codeine, 0.025 mumol/l for ethylmorphine and 0.032 mumol/l for morphine (corresponding to 7.8, 7.8 and 9.1 micrograms/l, respectively). The analytical variations at concentrations of 1.0 mumol/l codeine, 1.0 mumol/l ethylmorphine and 0.5 mumol/l morphine were less than 5%.

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