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Evaluation of 6-([18F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain

✍ Scribed by Alicia E. Reid; Jacob Hooker; Elena Shumay; Jean Logan; Colleen Shea; Sung Won Kim; Shanika Collins; Youwen Xu; Nora Volkow; Joanna S. Fowler


Book ID
116799296
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
805 KB
Volume
36
Category
Article
ISSN
0969-8051

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Radiosynthesis of 6-([18F]fluoroacetamid
✍ Uday Mukhopadhyay; William P. Tong; Juri G. Gelovani; Mian M. Alauddin πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 French βš– 290 KB

## Abstract Radiosynthesis of a novel substrate for histone deacetylase (HDAC), 6‐([^18^F]fluoroacetamido)‐1‐hexanoicanilide ([^18^F]FAHA, [^18^F]‐**3**) is reported. For precursor synthesis, compound **1** (6‐amino‐1‐hexanoicanilide) was prepared by the reaction of 6‐amino hexanoic acid with thion