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Evaluation of 31P metabolite differences in human cerebral gray and white matter

✍ Scribed by Graeme F. Mason; Wen-Jang Chu; J. Thomas Vaughan; Steven L. Ponder; Donald B. Twieg; Dorothy Adams; Hoby P. Hetherington

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
829 KB
Volume
39
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

^31^P NMR is commonly used to study brain energetics in health and disease. Due to sensitivity constraints, the NMR measurements are typically made in volumes that do not contain pure gray or white matter. For accurate evaluation of abnormalities in brain metabolite levels, it is necessary to consider the differences in normal levels of ^31^P metabolites in gray and white matter. In this study, voxels from a three‐dimensional spectroscopic image acquisition were analyzed for their dependence on tissue type to assess differences in metabolite levels between gray and white matter. Specifically, gray matter was found to have significantly higher ratios of phosphocreatine (PCr) to γ‐ATP and PCr to the total ^31^P metabolite signal, whereas pH and the ratio of PCr to inorganic phosphate (P~1~) were found to differ insignificantly between gray and white matter. Thus, tissue type can be an important factor to consider for alterations in bioenergetics by ^31^P NMR spectroscopic studies of the brain.

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