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Eukaryotic topoisomerase II cleavage is independent of duplex DNA conformation

โœ Scribed by In Young Choi; In Kwon Chung; Mark T. Muller


Book ID
113263418
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
714 KB
Volume
1264
Category
Article
ISSN
0167-4781

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## Abstract The sequence specificity of topoisomeraseโ€IIโ€mediated DNA cleavage, stimulated by 2โ€methylโ€9โ€hydroxy ellipticinium and 4โ€ฒ, 5โ€ฒ,7โ€trihydroyflavone (genistein) was investigated by sequencing analysis of DNA cleavage sites and molecular modeling techniques. The former drug exhibits a marked