Conformational properties of topoisomera
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M. Palumbo; M. Mabilia; A. Pozzan; G. Capranico; S. Tinelli; F. Zunino
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Article
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1994
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John Wiley and Sons
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English
โ 527 KB
## Abstract The sequence specificity of topoisomeraseโIIโmediated DNA cleavage, stimulated by 2โmethylโ9โhydroxy ellipticinium and 4โฒ, 5โฒ,7โtrihydroyflavone (genistein) was investigated by sequencing analysis of DNA cleavage sites and molecular modeling techniques. The former drug exhibits a marked