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Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity

✍ Scribed by Betti, C J; Villalobos, M J; Jiang, Q; Cline, E; Diaz, M O; Loredo, G; Vaughan, A T M

Book ID
110056487
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
148 KB
Volume
19
Category
Article
ISSN
0887-6924

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## Abstract The location of __MLL__ translocation breakpoints within therapy‐related acute myeloid leukemia linked to drugs targeting Topoisomerase II and infant acute leukemia (IAL) are biased toward the intron 11–exon 12 region of __MLL__, although lacking a comprehensive explanation. To address