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Etoposide (VP-16) and cytosine arabinoside in the treatment of relapsed small-cell lung cancer


Book ID
123068079
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
162 KB
Volume
5
Category
Article
ISSN
0169-5002

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## Abstract Etoposide (VP16) is a potent inducer of DNA double‐strand breaks (DSBs) and is efficiently used in small cell lung cancer (SCLC) therapy. However, acquired VP16 resistance remains an important barrier to effective treatment. To understand the underlying mechanisms for VP16 resistance in